• Phytochemicals / Glycosides: (1) A methanolic extract study of leaves of A plumosus yielded two new furostanol glycosides (2) Study yielded three spirostanol glycosides from the leaves. 

Gardenia (Gardenia jasminoides)

Gardenia is a popular ornamental shrub best known for its glossy green leaves and large, intensely fragrant white flowers. As the flowers age, they gradually develop a yellowish color. In the Philippines, the double-flowered form is commonly cultivated as a garden plant.

Botanical Description

Gardenia is a smooth, hairless, branched shrub that generally grows between 1 and 2 meters tall.

Its leaves grow in opposite pairs and are typically elliptic to ovate in shape. They measure about 2 to 6 centimeters long and have pointed or narrowed ends. The leaves are glossy, short-stalked, and provided with stipules.

The flowers are among the most distinctive features of the plant. They are large, highly fragrant, and usually appear singly near the upper leaf axils. The green calyx has a funnel-shaped tube with five angles or wings and narrow lobes. The corolla is commonly double-flowered and white, although it turns yellowish as it matures. The flowers may reach approximately 5 to 8 centimeters across.

The fruit is yellow and ranges from ovoid to ellipsoid in shape. It is usually about 2.5 to 4.5 centimeters long and 1.5 to 2 centimeters wide, with several prominent longitudinal ridges. The fruit generally reaches maturity around November.

Constituents and Traditional Properties

Gardenia has a long history of traditional use in different systems of herbal medicine. Various parts of the plant have been described as having properties associated with fever, inflammation, digestion, urination, spasms, and certain skin conditions.

Chemical investigations of the fruit have identified several compounds, including imperatorin, isoimperatorin, crocetin, geniposide, crocin, crocin-3, and other flavonoid and chromone-related compounds. These constituents have attracted scientific interest because some have demonstrated antioxidant and other biological activities in laboratory studies.

It is important to distinguish traditional uses from scientifically established medical treatments. Research on gardenia compounds is ongoing, and laboratory or animal findings do not necessarily mean that the plant is proven to treat the same conditions in people.

Distribution and Cultivation

Gardenia is widely grown as an ornamental plant because of its attractive foliage and strongly scented flowers. In the Philippines, the double-flowered form is the form commonly encountered.

It can be cultivated in gardens and other suitable growing environments where its fragrant flowers can be appreciated.

Parts Used

Traditionally, the roots, leaves, and fruits have been used.

For traditional preparation, fruits may be gathered from approximately August through October and dried after the stems are removed. Roots are generally washed, cut into smaller sections, and dried in the sun.

Traditional Uses

Gardenia has been used traditionally in several ways. Preparations made from its leaves and flowers have been used for digestive complaints such as indigestion, excessive gas, and abdominal discomfort. Some traditional practices also associate the plant with nervous complaints and fever.

Other reported traditional applications include:

• Using flower preparations as a wash for irritated or inflamed eyes.
• Applying poultices made from leaves to swollen breasts.
• Using preparations of the bark traditionally for fever, dysentery, and abdominal discomfort.
• Using the fruit in traditional preparations for jaundice and other liver-related complaints.
• Applying powdered or prepared fruit externally to certain skin problems, including boils and sores.
• Using the plant traditionally for cough, fever, toothache, and other inflammatory complaints.
• Including gardenia fruit in traditional remedies for conditions such as edema and certain lymphatic disorders.

Historical herbal practices have also reported the use of gardenia fruit in traditional Chinese and Oriental medicine for conditions involving inflammation, jaundice, headache, fever, liver complaints, and high blood pressure.

Traditional dosage recommendations vary considerably depending on the plant part and preparation. Such historical doses should not be treated as modern medical dosing instructions, particularly because concentrated herbal preparations can have side effects or interact with medicines.

What Research Says

Modern research has investigated several compounds found in Gardenia jasminoides, particularly crocin, geniposide, and genipin.

Antioxidant Activity

Crocin is a water-soluble carotenoid found in gardenia fruit. Laboratory research suggests that it has antioxidant activity, meaning it may help counter oxidative processes under experimental conditions.

Diabetes Research

Genipin, a compound associated with gardenia, has received attention in diabetes research. Experimental studies have investigated its effects on UCP2, a protein involved in pancreatic beta-cell function and insulin secretion. These findings are interesting but should be considered preliminary rather than proof that gardenia can treat diabetes.

Antiangiogenic Activity

Researchers have also examined extracts of gardenia fruit for antiangiogenic activity—the ability to interfere with the formation of new blood vessels. Certain fractions of the plant extract have shown activity in laboratory assays.

Pancreatitis Research

Animal research has explored whether gardenia preparations could protect against experimentally induced acute pancreatitis. In one study, pretreatment with Gardenia jasminoides extract reduced the severity of pancreatitis induced in rats. Further research is needed to determine whether similar effects occur in humans.

Research Related to Alzheimer's Disease

Gardenia extracts and their constituents have also been investigated in laboratory models related to Alzheimer's disease. Some experiments have examined whether gardenia compounds can reduce the damaging effects of amyloid-beta peptides on cultured nerve cells, potentially through effects on oxidative stress.

These findings are promising areas for research, but they do not establish gardenia as a treatment or cure for Alzheimer's disease.

Immunological Research

Several compounds isolated from gardenia fruit have demonstrated immunological activity in laboratory studies. Some were found to inhibit certain forms of T-cell activation and interleukin-2 secretion. This may help researchers understand the plant's biological effects, although more work is necessary before drawing conclusions about therapeutic use in humans.

Availability

Gardenia is commonly cultivated as an ornamental plant and is widely found in gardens. It is also available as a cultivated plant for decorative purposes.

Final Thoughts

Gardenia is much more than a fragrant garden shrub. Its beautiful flowers, distinctive fruit, and long history of traditional use have made Gardenia jasminoides an interesting subject for both herbal traditions and modern scientific research.

Although laboratory and animal studies have identified potentially useful biological activities in gardenia compounds, these findings should not be confused with proven medical treatments. Anyone considering gardenia or gardenia-based preparations for a health condition should consult a qualified healthcare professional, especially when taking prescription medicines.

Gen Info 

Worldwide production of annatto seeds for commercial and home use.

 
• Depressant: Neuropharmacological Effects of Aqueous Leaf Extract of Bryophyllum Pinnatum in Mice: Study revealed CNS depressant activity of the aqueous leaf extract that could be due to the presence of bufadienolide.
• Antinociceptive / Anti-inflammatory / Hypoglycemic: Leaf extract study of BP on animals showed it to possess antinociceptive, anti-inflammatory and hypoglycemic properties probably due to the flavonoid, polyphenol and triterpenoid contents.
• Antiulcer: Results of methanolic extract study in rats showed that BP possessed potent antiulcer properties. Leaf extract showed significant reduction in incidence of ulceration in indomethacin-induced gastric ulceration in a dose-dependent manner.
• Tocolytic / Pre-term labor: (1) Study characterized the tocolytic activity of Bp in vitro vs the betamimetic, fenoterol. Results confirmed its tocolytic activity and justifies further clinical studies. (2) Intravenous tocolysis with Bryophyllum pinnatum is better tolerated than beta-agonist application.
• Analgesic: The study concludes that the aqueous extract of BP has strong analgesic potency comparable in a times- and dose-dependent manner to a nonsteroidal anti-inflammatory drug.
• Antileishmanial: The antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata: Quercetin from K pinnata has demonstrated to be a potent antileshmanial flavonoid. Another study yielded unusual flavonoids with antileishmanial effect.
• Cytotoxic: A study isolated a potent cytotoxic bufadienolide orthoacetate and identified as bersaldegenin 1,3, 5-orthoacetate.
• Antimicrobial: Extract of leaves showed activity against all test organisms except for Candida albicans. Of all the extracts of Bp, themethanol extract was the most active with marked antibacterial activities against control strain of S aureus, E faecalis, B subtilis and P aeruginosa.

 
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